{"id":549,"date":"2020-06-05T15:14:13","date_gmt":"2020-06-05T18:14:13","guid":{"rendered":"https:\/\/www.agb.org.br\/covid19\/?p=549"},"modified":"2020-06-05T15:42:09","modified_gmt":"2020-06-05T18:42:09","slug":"challenges-and-cares-to-promote-rational-use-of-chloroquine-and-hydroxychloroquine-in-the-management-of-coronavirus-disease-2019-covid-19-pandemic-a-timely-review","status":"publish","type":"post","link":"https:\/\/www.agb.org.br\/covid19\/2020\/06\/05\/challenges-and-cares-to-promote-rational-use-of-chloroquine-and-hydroxychloroquine-in-the-management-of-coronavirus-disease-2019-covid-19-pandemic-a-timely-review\/","title":{"rendered":"Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review"},"content":{"rendered":"<p><b>Abstract:<\/b><span style=\"font-weight: 400\"> As a result of the 2019 coronavirus disease pandemic (COVID-19), there has been an urgent worldwide demand for treatments. Due to factors such as history of prescription for other infectious diseases, availability, and relatively low cost, the use of chloroquine (CQ) and hydroxychloroquine (HCQ) has been tested\u00a0<\/span><i><span style=\"font-weight: 400\">in vivo<\/span><\/i><span style=\"font-weight: 400\">\u00a0and\u00a0<\/span><i><span style=\"font-weight: 400\">in vitro<\/span><\/i><span style=\"font-weight: 400\">\u00a0for the ability to inhibit the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, even though investigators noted the therapeutic potential of these drugs, it is important to consider the toxicological risks and necessary care for rational use of CQ and HCQ. This study provides information on the main toxicological and epidemiological aspects to be considered for prophylaxis or treatment of COVID-19 using CQ but mainly HCQ, which is a less toxic derivative than CQ, and was shown to produce better results in inhibiting proliferation of SARS-CoV-2 based upon preliminary tests.<\/span><\/p>\n<p><b>Keywords:<\/b><span style=\"font-weight: 400\">\u00a0<\/span><span style=\"font-weight: 400\">T<\/span><span style=\"font-weight: 400\">oxicology<\/span><span style=\"font-weight: 400\">,\u00a0<\/span><span style=\"font-weight: 400\">screening<\/span><span style=\"font-weight: 400\">,\u00a0<\/span><span style=\"font-weight: 400\">health care<\/span><span style=\"font-weight: 400\">,\u00a0<\/span><span style=\"font-weight: 400\">retinopathy<\/span><span style=\"font-weight: 400\">,\u00a0<\/span><span style=\"font-weight: 400\">public health\u00a0<\/span><\/p>\n<p>Para acessar o artigo completo clique<strong> <a href=\"https:\/\/www.agb.org.br\/covid19\/wp-content\/uploads\/2020\/06\/Boscolli_Pereira_Challenges-and-cares-to-promote-rational-use-of-chloroquine-and-hydroxychloroquine-in-the-management-of-coronavirus-disease-2019-COVID-19-pandemic-a.pdf\">aqui.<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: As a result of the 2019 coronavirus disease pandemic (COVID-19), there has been an urgent worldwide demand for treatments. Due to factors such as history of prescription for other infectious diseases, availability, and relatively low cost, the use of chloroquine (CQ) and hydroxychloroquine (HCQ) has been tested\u00a0in vivo\u00a0and\u00a0in vitro\u00a0for the ability to inhibit the [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50,45],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.4.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review - Observat\u00f3rio Geogr\u00e1fico<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agb.org.br\/covid19\/2020\/06\/05\/challenges-and-cares-to-promote-rational-use-of-chloroquine-and-hydroxychloroquine-in-the-management-of-coronavirus-disease-2019-covid-19-pandemic-a-timely-review\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review - Observat\u00f3rio Geogr\u00e1fico\" \/>\n<meta property=\"og:description\" content=\"Abstract: As a result of the 2019 coronavirus disease pandemic (COVID-19), there has been an urgent worldwide demand for treatments. Due to factors such as history of prescription for other infectious diseases, availability, and relatively low cost, the use of chloroquine (CQ) and hydroxychloroquine (HCQ) has been tested\u00a0in vivo\u00a0and\u00a0in vitro\u00a0for the ability to inhibit the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.agb.org.br\/covid19\/2020\/06\/05\/challenges-and-cares-to-promote-rational-use-of-chloroquine-and-hydroxychloroquine-in-the-management-of-coronavirus-disease-2019-covid-19-pandemic-a-timely-review\/\" \/>\n<meta property=\"og:site_name\" content=\"Observat\u00f3rio Geogr\u00e1fico\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-05T18:14:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-05T18:42:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.agb.org.br\/covid19\/wp-content\/uploads\/2020\/05\/obs.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"886\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Amanda baratelli\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.agb.org.br\/covid19\/#organization\",\"name\":\"Observat\u00f3rio geogr\u00e1fico\",\"url\":\"https:\/\/www.agb.org.br\/covid19\/\",\"sameAs\":[],\"logo\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.agb.org.br\/covid19\/#logo\",\"inLanguage\":\"pt-BR\",\"url\":\"https:\/\/www.agb.org.br\/covid19\/wp-content\/uploads\/2020\/05\/obs.jpeg\",\"contentUrl\":\"https:\/\/www.agb.org.br\/covid19\/wp-content\/uploads\/2020\/05\/obs.jpeg\",\"width\":1280,\"height\":886,\"caption\":\"Observat\u00f3rio geogr\u00e1fico\"},\"image\":{\"@id\":\"https:\/\/www.agb.org.br\/covid19\/#logo\"}},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.agb.org.br\/covid19\/#website\",\"url\":\"https:\/\/www.agb.org.br\/covid19\/\",\"name\":\"Observat\u00f3rio Geogr\u00e1fico\",\"description\":\"Sobre os impactos da Covid-19\",\"publisher\":{\"@id\":\"https:\/\/www.agb.org.br\/covid19\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.agb.org.br\/covid19\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.agb.org.br\/covid19\/2020\/06\/05\/challenges-and-cares-to-promote-rational-use-of-chloroquine-and-hydroxychloroquine-in-the-management-of-coronavirus-disease-2019-covid-19-pandemic-a-timely-review\/#webpage\",\"url\":\"https:\/\/www.agb.org.br\/covid19\/2020\/06\/05\/challenges-and-cares-to-promote-rational-use-of-chloroquine-and-hydroxychloroquine-in-the-management-of-coronavirus-disease-2019-covid-19-pandemic-a-timely-review\/\",\"name\":\"Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review - 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